Table 2.
Outline of ontology search strategies
|
Pain Ontologies: | |
| A. Biological Process: | |
| 1. Sensory perception | |
| a. Sensory perception of pain: | |
| I. Regulation of sensory perception of pain | |
| II. Detection of chemical stimulus involved | |
| III. Detection of temperature stimulus involved | |
| IV. Detection of mechanical stimulus involved | |
| 2. Ion transport | |
| 3. Inflammatory response | |
| 4. Behavior | |
| 5. Response to pain: | |
| a. Behavioral response to pain | |
| 6. G-protein coupled receptor (protein) signaling pathway | |
| 7. Transmission of nerve impulse | |
| 8. Fatty acid catabolic process | |
| B. Molecular Function: | |
| 1. 1. Carboxyl- or carbamoyl-transferase activity | |
| 2. Opioid peptide activity | |
| 3. Signal transducer activity | |
| a. G-protein coupled receptor activity | |
| b. Galanin receptor activity | |
| c. Bradykinin receptor activity | |
| d. Opioid receptor activity | |
| e. Adrenergic receptor activity | |
| 4. Voltage-gated channel activity | |
| 5. G-protein coupled receptor binding | |
| C. Cellular component | |
| 1. Plasma lipoprotein particle | |
| 2. Axon | |
|
Nerve Ontologies: | |
| A. Biological Process: | |
| 1. Neuron death | |
| a. Neuron apoptosis | |
| i. Positive regulation of neuron apoptosis | |
| ii. Negative regulation of neuron apoptosis | |
| a. Neurotrophin production | |
| iii. Neuroprotection | |
| 2. Neuropeptide signaling pathway |
|
| 3. Transmission of nerve impulse |
|
| 4. Nervous system development: |
|
| a. Nerve development |
|
| b. Neurogenesis |
|
| i. Regulation of neurogenesis |
|
| a. Positive regulation of neurogenesis |
|
| b. Negative regulation of neurogenesis |
|
| ii. Neuron differentiation |
|
| a. Neuron projection development |
|
| i. Axonogenesis regulation: |
|
| a. Positive regulation of axonogenesis |
|
| b. Negative regulation of axonogenesis |
|
| iii. Neuroblast differentiation |
|
| iv. Neuroblast proliferation |
|
| v. Neuron migration |
|
| B. Molecular function: |
|
| 1. Neurotrophin binding: |
|
| a. Nerve growth factor binding |
|
| 2. Neurotrophin receptor activity |
|
| 3. Neurotransmitter receptor activity |
|
| a. Substance P receptor activity |
|
| 4. Calcitonin receptor binding |
|
| 5. Vascular endothelial growth factor (-activated) receptor activity |
|
| 6. Protein kinase activity |
|
| 7. Neuropeptide hormone activity |
|
| 8. Neuropeptide binding |
|
| 9. Ciliary neurotrophic factor receptor binding |
|
| 10. Neurotrophin receptor binding: |
|
| a. Nerve growth factor receptor binding |
|
| C. Cellular component: |
|
| 1. Neuron projection: |
|
| a. Axon |
|
| b. Dendrite |
|
| 2. Endoplasmic reticulum lumen |
|
| 3. Nuclear outer membrane |