TABLE 3.

Up- and downregulated genes in blood samples of patients who underwent MARS therapy

Gene ID	Gene symbol	Gene name	Mean fold-change	Individual fold change
				Patient 1	Patient 2	Patient 3
1960	EGR3	Early growth response 3	3.73	5.10	1.70	4.39
9865	TRIL	TLR4 interactor with leucine-rich repeats	−2.58	−1.51	−4.52	−1.70
375010	LOC375010	Ankyrin repeat domain 20 family, member A pseudogene	−2.54	−3.03	−2.65	−1.94
27023	FOXB1	Forkhead box B1	2.50	1.62	3.64	2.23
81127	OR4K15	Olfactory receptor, family 4, subfamily K, member 15	−2.50	−1.77	−1.71	−4.01
219493	OR5AR1	Olfactory receptor, family 5, subfamily AR, member 1	−2.49	−1.64	−3.36	−2.46
153579	BTNL9	Butyrophilin-like 9	−2.46	−3.05	−1.58	−2.75
136371	ASB10	Ankyrin repeat and SOCS box-containing 10	2.38	1.84	3.15	2.16
6288	SAA1	Serum amyloid A1	2.35	1.74	3.58	1.74
25790	CCDC19	Coiled-coil domain containing 19	−2.37	−2.54	−2.43	−2.13
1943	EFNA2	Ephrin-A2	2.27	2.14	1.83	2.83
2047	EPHB1	Ephrin receptor B1	−2.26	−2.44	−1.51	−2.84
4108	MAGEA9	Melanoma antigen family A, 9	−2.20	−2.24	−1.64	−2.71
79933	SYNPO2L	Synaptopodin 2-like	−2.16	−1.82	−3.14	−1.52
643444	LOC643444	Similar to WAS protein homology region 2 domain containing 1-like 1	2.12	2.03	2.44	1.89
2128	EVX1	Even-skipped homeobox 1	2.09	2.69	1.85	1.73
392583	LOC392583	Hypothetical LOC392583	2.07	1.68	3.00	1.53
2232	FDXR	Ferredoxin reductase	2.01	1.53	2.90	1.61
22854	NTNG1	Netrin G1	2.01	1.58	2.76	1.68
55701	ARHGEF40	Rho guanine nucleotide exchange factor (GEF) 40	−2.01	−2.42	−1.98	−1.64

Values represent fold-change increase (normalized expression post/normalized expression pre) or decrease (–1/[normalized expression post/normalized expression pre]) for each individual patient and genes are sorted according to the absolute mean fold-change observed in the group. ID Identification; MARS Molecular adsorbent recirculating system; TLR Toll-like receptor; WAS Wiskott-Aldrich syndrome