Figure 3. Bisulfite genomic sequencing of the CpG islands associated with the snoRNAs U88, U19–2, U63 and ACA49 in normal colon and the colorectal cancer cell line HCT-116. CpG dinucleotides are represented as short vertical lines. Eight single clones are represented for each sample. Presence of a methylated or unmethylated cytosine is indicated by a black or white square, respectively. Transcription start sites are represented by vertical black arrows.