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. 2012 Nov 12;7(11):e49252. doi: 10.1371/journal.pone.0049252

Figure 2. GroEL protein preferentially activates CD4+ T cells.

Figure 2

Following 24 h and 48 h stimulation of PBMCs with rAaGroEL (20 µg/ml), cells were labeled with anti-CD3, anti-CD4, anti-CD8, anti-CD69 and anti-CD25 antibodies. CD8+ and CD4+ gated T cells were analyzed for CD69 and CD25 expressions. (A) CD69 expression of CD4+ and CD8+ T cells at 24 h and 48 h. (B) CD25 expression of CD4+ and CD8+ T cells at 24 h and 48 h. (C) Representative distribution of PBMCs and CD69 and CD25 expressing rAaGroEL responding CD4+ T cells. Data are representative of experiments with cells from 3 donors. Error bars represent standard deviation and *indicates p<0.05.