Table 3.
Pleural fluid DNA fragments, integrity index and mesothelin in subjects with malignant and benign pleural effusions
| All MPE(n= 52) | Malignant pleural mesothelioma only (n = 16) | Lung cancer (n=22) | Other cancers (n=14) | BPE(n= 23) | ||
|---|---|---|---|---|---|---|
| ALU 115 (ng/ml) |
p-value |
0.217 |
0.509 |
0.147 |
0.526 |
|
| |
Mean, Range |
1841.6 |
1512.2 |
2065.0 |
1836.6 |
1616.7 |
| |
|
(21.8-6328.7) |
(41.7 – 5964.2) |
(21.8 – 6204.8) |
(176.5 – 6328.7) |
(48.5 – 7814.9) |
| |
Median (IQR 25-75) |
963.9 |
712.3 |
1366.5 |
723.5 |
520.3 |
| |
|
(411.1-2385.7) |
(502.3 – 1992.9) |
(488.4 – 2624.0) |
(299.1 – 4492.1) |
(128.6 – 2481.9) |
| ALU 247 (ng/ml) |
p-value |
0.066 |
0.187 |
0.061 |
0.231 |
|
| |
Mean, Range |
2065.7 |
1827.6 |
1947.8 |
2694.1 |
1389.4 |
| |
|
(23.5 – 9973.7) |
(23.5 – 7220) |
(71.5 – 6671.4) |
(151.7 – 9973.7) |
(8.2 – 7126) |
| |
Median (IQR 25-75) |
1186.2 |
1047.8 |
1368.0 |
1060.4 |
371.8 |
| |
|
(397.7 – 2616.5) |
(580.7 – 2353.7) |
(346.9 – 2660.3) |
(267.4 – 6894.9) |
(85.5 – 2036.6) |
| DNA integrity index |
p-value |
<0.001 |
<0.001 |
0.018 |
<0.001 |
|
| |
Mean, Range |
1.2 |
1.2 |
1.09 |
1.25 |
0.8 |
| |
|
(0.4 – 3.3) |
(0.6 – 1.9) |
(0.4 – 3.3) |
(0.6 – 1.8) |
(0.0 – 1.5) |
| |
Median (IQR 25-75) |
1.1 |
1.2 |
0.9 |
1.3 |
0.8 |
| |
|
(0.8 – 1.5) |
(0.9 – 1.6) |
(0.7 – 1.2) |
(0.9 – 1.6) |
(0.7 – 0.9) |
| Mesothelin, nM |
p-value |
0.242 |
<0.001 |
0.533 |
0.132 |
|
| |
Mean, Range |
36.9 |
104.2 |
8.0 |
5.5 |
7.4 |
| |
|
(1-392) |
(4 – 392) |
(1-31) |
(0.7 – 24.5) |
(1- 36) |
| |
Median (IQR 25-75) |
6.06 |
38.0 |
4.6 |
3.1 |
4.6 |
| (3.1 – 19.0) | (10.8 – 106.5) | (3 – 11.7) | (1.8 – 8.4) | (2.6 – 8.4) |
*p-value-Mann-Whitney U test comparing diagnoses with benign effusions.