Table 5.
Serum DNA fragments, integrity index and mesothelin in subjects with malignant and benign pleural effusions
| All MPE(n= 52) | MPM (n = 16) | Lung cancer (n=22) | Other cancers (n=14) | BPE(n= 23) | ||
|---|---|---|---|---|---|---|
| ALU 115 (ng/ml) |
p-value |
0.599 |
0.198 |
0.855 |
0.777 |
|
| |
Mean, Range |
796.7 (6 – 5438) |
503.7 (23 – 2869) |
851.6 (6.3 - 4150.4) |
1072.9 (31.8 – 5438.4) |
826.8 (9 – 3835) |
| |
Median (IQR 25-75) |
234.4 (47.6 – 1107.9) |
123.1 (36.5 – 321.4) |
431.6 (47.1 – 1240.3) |
500.2 (88.6 – 1113.8) |
695.4 (59.1 – 1238.9) |
| ALU 247 (ng/ml) |
p-value |
0.968 |
0.667 |
0.955 |
0.512 |
|
| |
Mean, Range |
1088.3 (0 – 11995) |
566.9 (10 – 3520) |
1084.9 (0.1 – 7220.6) |
1689.0 (11.7 – 11995.4) |
930.7(2 – 2946) |
| |
Median (IQR 25-75) |
226.1 (31.6 – 1161.5) |
157.7 (16.6 – 274.7) |
333.6 (26.3 – 1458.4) |
309.8 (50.7 – 1853.7) |
330.2 (8.8 – 1832.7) |
| DNA integrity index |
p-value |
0.461 |
0.408 |
0.849 |
0.409 |
|
| |
Mean, Range |
1.0 (0 – 4.1) |
1.1 (0.3 – 4.1) |
0.9 (0.0 – 2.1) |
1.1 (0.3 – 2.2) |
1.0 (0 – 4.2) |
| |
Median (IQR 25-75) |
0.9 (0.5 – 1.3) |
1.0 (0.5 – 1.2) |
1.0 (0.4 – 1.3) |
1.0 (0.6 – 1.5) |
0.9 (0.5 – 1.0) |
| Mesothelin, nM |
p-value |
0.071 |
<0.001 |
0.692 |
0.552 |
|
| |
Mean, Range |
2.5 (0 - 32) |
4.9 (1- 32) |
1.2 (0 – 5) |
1.2 (0.4 – 3.2) |
1.0 (0 – 4) |
| Median (IQR 25-75) | 1.2 (0.7 – 2.2) | 2.0 (1.3 – 3.5) | 0.7 (0.5 – 1.3) | 1.0 (0.6 – 1.6) | 0.8 (0.5 – 1.2) | |
*p-value-Mann-Whitney U test comparing diagnoses with benign effusions.