Table 1. Centrosome localization and centrosome amplification suppression of HDACs.
| |
Centrosome localization |
Suppression of cent. amplification |
||
|---|---|---|---|---|
| HDACs | Unduplicated | Duplicated | *Level | Actual frequency(%)** |
| Control |
NA |
NA |
NA |
41.1 ± 2.3 |
| HDAC1 |
+ |
+ |
++ |
16.8 ± 3.6 |
| HDAC2 |
– |
– |
– |
41.0 ± 1.0 |
| HDAC3 |
– |
– |
+ |
34.5 ± 4.0 |
| HDAC4 |
+ |
+ |
+ |
28.0 ± 1.6 |
| HDAC5 |
+ |
– |
++ |
17.6 ± 4.2 |
| HDAC6 |
± * |
– |
+ |
34.0 ± 1.8 |
| HDAC7 |
– |
– |
– |
43.7 ± 3.0 |
| HDAC8 |
– |
– |
+ |
34.8 ± 3.7 |
| HDAC9 |
– |
– |
– |
42.7 ± 1.6 |
| HDAC10 |
+ |
+ |
+ |
29.4 ± 4.4 |
| HDAC11 |
+ |
+ |
+ |
28.5 ± 5.4 |
| SIRT1 |
+ |
+ |
++ |
20.0 ± 2.3 |
| SIRT2 |
+ |
+ |
– |
41.7 ± 1.9 |
| SIRT3 |
– |
– |
– |
40.8 ± 1.7 |
| SIRT4 |
– |
– |
+ |
33.2 ± 1.3 |
| SIRT5 |
– |
– |
– |
39.6 ± 1.7 |
| SIRT6 |
– |
– |
– |
40.6 ± 1.7 |
| SIRT7 | – | – | – | 37.7 ± 1.0 |
* If the frequency of centrosome amplification is reduced to 70–85% of the control, suppression of centrosome amplification is labeled as +, and if it is reduced to < 50% of the control, suppression of centrosome amplification is labeled as ++. **Actual frequency of centrosomes amplification is shown as the means ± SD (see Fig. 3). *HDAC6 was found at unduplicated centrosomes in ~25% of cells. NA, not applicable.