Table 1.

Updated definition of organ involvement in AL amyloidosis

Involved organ or tissue	Criteria
Kidney	24-hr urine protein > = 0.5 g/day, predominantly albumin
Heart	NT-proBNP > 332 ng/l (in the absence of renal failure or atrial fibrillation) or mean wall thickness in diastole by echography > 12 mm, no other cardiac cause
Liver	Total liver span > 15 cm in the absence of heart failure, or alkaline phosphatase > 1.5 times institutional upper limit of normal
Nerve	Peripheral: Symmetric lower extremity sensorimotor peripheral neuropathy
	Autonomic: gastric-emptying disorder, pseudo-obstruction,voiding dysfunction not related to direct organ infiltration.
Gastro-intestinal tract	Direct biopsy verification with symptoms
Lung	Direct biopsy verification with symptoms
	Interstitial radiographic pattern
Soft tissues	Tongue enlargement, arthropathy, claudication (presumed vascular amyloid), skin lesions, myopathy (by biopsy or pseudohypertrophy), lymph node (may be localized), carpal tunnel syndrome

From Gertz et al. ( 3,4) with permission.