Table 3.
Results of main multicenter and single-center studies of HDM/SCT in AL amyloidosis
| Authors (references) | Year of publication and N° of patients | Clonal response% (PR + CR) | CR% | TRM% | Median survival (years) |
|---|---|---|---|---|---|
| Single center studies | |||||
| Skinner et al. [54] |
2004/312 |
NA |
40 ** |
13 |
4,6 ** |
| Sanchorawala et al. [55] |
2007/80 |
NA |
37 ** |
18 |
4,75 ** |
| Schonland et al. [56] |
2010/58 |
74 * |
46 * |
17 |
> 8 * |
| Cibeira et al. [57] |
2011/421 |
NA |
34 ** |
11,4 |
6,3 ** |
| Madan et al. [58] |
2012/187 |
66 ** |
30 ** |
15 |
4,5 ** |
| Multicenter studies | |||||
| Vesole et al. [59] |
2003/107 |
32 ** |
16 ** |
27 |
3,9 ** |
| Goodman et al. [60] |
2006/92 |
66 ** |
35 ** |
23 |
5,3 ** |
| Jaccard et al. [21] | 2007/50 | 36 * | 22 * | 26 | 1,8 * |
* Intent to treat after inclusion in an intensive treatment program **only after intensive treatment.