Table 2.
Receiver operating characteristics curve (ROC) analysis using tissue and plasma miRNAs expression for discriminating endometrioid endometrial cancer (EEC) samples
| miRNA/miRNA signature | AUC [95% CI] | p | Sensitivity | Specificity | C | +PV | -PV |
|---|---|---|---|---|---|---|---|
| Tissues (EEC n = 73, NE n= 31) | |||||||
| miR-99a |
0.675 [0.572-0.767] |
0.006 |
0.88 |
0.5 |
6.6 |
81.3 |
63.6 |
| miR-100 |
0.652 [0.548-0.746] |
0.03 |
0.86 |
0.5 |
6.5 |
80.8 |
58.3 |
| miR-199b |
0.706 [0.606-0.794] |
0.001 |
0.81 |
0.71 |
5.3 |
87.5 |
60.6 |
| miR-99a/miR-100/miR-199b |
0.774 [0.678-0.853] |
<0.0001 |
0.61 |
0.89 |
0.76 |
93.3 |
48.1 |
| Plasma (EEC n = 34, NE n = 14) | |||||||
| miR-99a |
0.810 [0.669-0.909] |
<0.0001 |
0.76 |
0.79 |
1.23 |
89.3 |
57.9 |
| miR-100 |
0.740 [0.592-0.857] |
0.001 |
0.64 |
0.79 |
1.5 |
33.3 |
92.8 |
| miR-199b |
0.786 [0.642-0.892] |
0.0002 |
0.79 |
0.71 |
2.48 |
86.7 |
58.8 |
| miR-99a/miR-199b | 0.903 [0.780-0.970] | <0.0001 | 0.88 | 0.93 | 0.73 | 96.7 | 76.5 |
AUC - area under curve; 95% CI – 95% confidence interval; C - factor; +PV - positive predictive value; -PV - negative predictive value.