Skip to main content
. 2012 Nov 12;7(11):e49275. doi: 10.1371/journal.pone.0049275

Figure 3. Inhibitory effect of p-Hsp27 and enhancement of apoptosis by Qu in DRSPs.

Figure 3

(A) An MTT assay demonstrated that Qu treatment at a dose of 100 µM combined with Cis can suppress DRSPs. Qu attenuated the expression of the products of the drug-resistance-related genes ABCG2 and MDR-1 in a dose-dependent manner. (B) Both the knockdown of Hsp27 and the use of Qu combined with Cis effectively induced similar apoptotic effects that led to the decrease of pHsp27 and upregulation of CI-caspase 3 and CI-PARP in DRSPs. (C) Treatment with Qu combined with Cis markedly decreased the migration and invasion abilities in DRSPs. (D) Treatment with Qu combined with Cis reversed the expression of EMT-associated markers and induced the EMT phenomenon.