Table 1.
Effects of theophylline (50 mg/kg bw) on body composition in rats bearing the Yoshida AH-130 ascites hepatoma
| |
|
Experimental group |
|
|
|
|---|---|---|---|---|---|
| |
C(n = 6) |
T(n = 10) |
T + TPH(n = 7) |
ANOVA |
|
| A | B | ||||
|
Fat mass (g) |
3.2 ± 1.1 |
−4.3 ± 0.5 |
−2.3 ± 0.7 |
0,000 |
0,045 |
|
Lean body mass (g) |
23.5 ± 1.5 |
1.7 ± 1.7 |
7 ± 3 |
0,000 |
ns |
| Fluids (g) | 0.03 ± 0.2 | −0.7 ± 0.2 | 0.04 ± 0.3 | 0,034 | 0,025 |
Results are expressed as the difference between day 0 (tumour inoculation) and day 7; mean ± SEM. C = non-tumour-bearing rats, T = tumour-bearing rats, T + TPH = tumour-bearing rats treated with theophylline. Statistical significance of the results by two-way analysis of variance (ANOVA); ns: non-significant differences. A (tumour effect); B (treatment effect).