Figure 1. Relative solvent-exposed surface area for basic residues of the Heparin Binding Site:

The SASA is calculated relative to a reference fully solvent-exposed residue present in a tripeptide. (A) Antithrombin's PBS (PDB ID = 1TB6). (B) Thrombin's exosite II (PDB ID = 1XMN, AB subunits). The exposed Connolly surface was calculated by rolling a sphere of 1.4 Å on the surface. See Methods for details.