Table 3. Calculated HINT characteristics of the water molecules in the binding site water array [42].

Monomer Name	TOTAL for water*			Probability†		Weighting†		Relevance Prediction‡
	Rank	Score	Relevance	Rank	Score	Rank	Score
HOH1	1.863	44.1	0.357	0.504	0.297	−0.064	−0.658	non-conserved
HOH2	2.058	57.0	0.390	0.551	0.320	0.103	−0.658	non-conserved
HOH3	0.902	−74.2	0.174	0.244	0.072	−1.000	−0.658	non-conserved
HOH4	0.000	−79.5	−0.040	−0.040	0.061	−21.136	−0.658	non-conserved
Mean	1.206	−13.2	0.221

^*Total Rank, HINT score and Relevance for water with respect to the protein.

^†The Probabilities and Weightings are components of the empirical Bayesian-like Relevance equation – see reference 40.

^‡The Relevance model is built on the premise [41] that Relevance ≥0.50 represents the characteristics of a highly conserved water.