Table 1.
Demographics of two distinct cohort of women at high risk for Lynch syndrome (LS) -associated endometrial cancer (EC)
| Variable | Cohort 1 (cross-sectional cohort) N=77 Number (column %) |
Cohort 2 at baseline (longitudinal cohort) N=40 Number (column %) |
|---|---|---|
| Demographics | ||
| Mean age (range) | 41.4 (20–70) | 43.6 (20–70) |
| <40 Years old | 35 (45) | 13 (33) |
| 40–49 Years old | 24 (31) | 18 (45) |
| ≥50 Years old | 17 (22) | 9 (23) |
| Unknown/missing | 1(1) | 0 (0) |
| Educational level | ||
| Less than college graduate | 23 (30) | 3 (8) |
| At least college graduate | 54 (70) | 26 (90) |
| Unknown/missing | 0 (0) | 1 (3) |
| Annual income | ||
| <$50,000 | 15 (19) | 5 (13) |
| >$50,000 | 57 (74) | 33 (83) |
| Unknown/missing | 5 (6) | 2 (5) |
| Marital status | ||
| Married | 58 (75) | 30 (75) |
| Not married | 18 (23) | 9 (23) |
| Unknown/missing | 1 (1) | 1 (3) |
| Health insurance | ||
| Yes | 76 (99) | 40 (100) |
| No | 1 (1) | 0 (0) |
|
Personal history and health practices |
||
| Personal cancer history | ||
| Have had any cancer | 30 (39) | 17 (43) |
| Have not had any cancer | 47 (61) | 22 (55) |
| Unknown/missing | 0 (0) | 1 (3) |
| Personal colorectal cancer (CRC) history |
||
| Have had CRC | 27 (35) | 9 (23) |
| Have not had CRC | 50 (65) | 31 (78) |
| Physician visits in the past year | ||
| 0 | 1 (1) | 1 (3) |
| 1–6 | 58 (75) | 26 (65) |
| ≥7 | 18 (23) | 11 (28) |
| Unknown/missing | 0 (0) | 2 (5) |
| Physician discussed cancer risk | ||
| Yes | 66 (86) | 33 (83) |
| No | 11 (14) | 7 (18) |
| CRC surveillance practicesa | ||
| Adequate CRC surveillancea | 55 (71) | 21 (53) |
| Inadequate CRC surveillancea | 22 (29) | 19 (48) |
| Family history | ||
| Fulfills Amsterdam Criteria | ||
| Yes | 65 (84) | 33 (83) |
| No | 12 (16) | 7 (18) |
| Known MMR mutation in the family |
||
| Yes | 49 (64) | 19 (48) |
| No | 28 (36) | 21 (53) |
| Family history of any LS cancer | ||
| Yes | 73 (95) | 39 (98) |
| No | 4 (5) | 1 (3) |
| 1st/2nd degree relative with EC | ||
| Yes | 33 (43) | 16 (40) |
| No | 44 (57) | 24 (60) |
| Genetic evaluation | ||
| Visited high-risk clinic | ||
| Yes | 64 (83) | 40 (100) |
| No | 13 (17) | 0 (0) |
| Genetic testing status | ||
| Had genetic testing | 58 (75) | 0 (0) |
| Have not had genetic testing | 19 (25) | 40 (100) |
| Genetic test result | ||
| Positive | 45 (58) | 0 (0) |
| Indeterminate/variant | 13 (17) | 0 (0) |
| True negative | 0 (0) | 0 (0) |
| Have not had genetic testing | 19 (25) | 40 (100) |
a
“Adequate colorectal cancer surveillance” defined as having colonoscopy at least every 2 years or being age <25