Table 2.
Factors associated with fulfillment of endometrial cancer (EC) risk-reducing guidelinesa among women at risk for Lynch syndrome (LS)-associated EC (Cohort 1 - cross-sectional cohort)
| Variable | Fulfilling guidelines a Number (row %) |
Not fulfilling guidelines a Number (row %) |
P valueb |
|---|---|---|---|
| Total cohort 1 (N=77) | 58 (75) | 19 (25) | |
| Demographics | |||
| Mean age (± SD) | 39.5 ± 11.1 | 47.3 ±9.9 | 0.01 |
| <40 Years old | 30 (86) | 5 (14) | 0.04 |
| 40–49 Years old | 18 (75) | 6 (25) | |
| ≥50 Years old | 9 (53) | 8 (47) | |
| Unknown/missing | 1(--) | 0(--) | |
| Educational level | |||
| Less than college graduate | 14 (61) | 9 (39) | 0.08 |
| At least college graduate | 44 (81) | 10 (19) | |
| Annual income | |||
| <$50,000 | 12 (80) | 3 (20) | 0.75 |
| ≥$50,000 | 42 (74) | 15 (26) | |
| Unknown/missing | 4(--) | 1(--) | |
| Marital status | |||
| Married | 46 (79) | 12 (21) | 0.13 |
| Not married | 11 (61) | 7 (39) | |
| Unknown/missing | 1 (--) | 0 (--) | |
|
Personal history and health practices |
|||
| Personal cancer history | |||
| Have had any cancer | 25 (83) | 5 (17) | 0.28 |
| Have not had any cancer | 33 (70) | 14 (30) | |
| Personal colorectal cancer (CRC) history |
|||
| Have had CRC | 22 (81) | 5 (19) | 0.42 |
| Have not had CRC | 36 (72) | 14 (28) | |
| Physician visits in the past year |
|||
| 0 | 1 (100) | 0 (0) | 0.82 |
| 1–6 | 44 (76) | 14 (24) | |
| ≥7 | 13 (72) | 5 (28) | |
| Physician discussed cancer risk |
|||
| Yes | 48 (73) | 18 (27) | 0.28 |
| No | 10 (91) | 1 (9) | |
| CRC surveillance practicesc |
|||
| Adequate CRC surveillancec | 47 (85) | 8 (15) | 0.03 |
| Inadequate CRC surveillancec | 11 (50) | 11 (50) | |
| Family history | |||
| Fulfills Amsterdam | |||
| Criteria | |||
| Yes | 48 (74) | 17 (26) | 0.72 |
| No | 10 (83) | 2 (17) | |
| Known MMR mutation in the family |
|||
| Yes | 42 (86) | 7 (14) | 0.01 |
| No | 16 (57) | 12 (43) | |
| 1st/2nd degree relative with EC |
|||
| Yes | 27 (82) | 6 (18) | 0.30 |
| No | 31 (70) | 13 (30) | |
| Genetic evaluation | |||
| Visited high-risk clinic | |||
| Yes | 52 (81) | 12 (19) | 0.01 |
| No | 6 (46) | 7 (54) | |
| Genetic testing status | |||
| Had genetic testing | 51 (88) | 7 (12) | <0.001 |
| Have not had genetic testing | 7 (37) | 12 (63) | |
| Genetic test result | |||
| Positive | 42 (93) | 3 (7) | 0.04 |
| Indeterminate/variant | 9 (69) | 4 (31) |
a
“Fulfilling guidelines” defined as either (1) having had a prophylactic hysterectomy, (2) reporting annual EC surveillance by transvaginal ultrasound and/or endometrial biopsy, and/or (3) age <35 years old
b
Fisher’s exact test was used for categorical values, and t-test was used for continuous variables
c
“Adequate colorectal cancer surveillance” defined as having colonoscopy at least every 2 years or being age <25