Table 1.

CKiD Study Measurements by Visit

Area	Measurement	Initial Visit	Follow-Up Visits
			Every 3 to 6 mo	Years 1, 3, 5, 7	Years 2, 4, 6, 8
General	Physical exam/ medical history	X	X	X	X
	Medication use	X	X	X	X
	Symptom checklist	X	X	X	X
Kidney	mGFR**	X		X
	Renal panel	X		X	X
	UPCR (first morning urine)	X		X	X
	Cystatin C-based eGFR	X		X
	serum creatinine***	X		X	X
	Local laboratory tests†	X		X	X
Cardiovascular	Echocardiogram			X
	ABPM			X
	Carotid IMT*			X
	Lipid profile			X
	Blood pressure	X	X	X	X
Neurocognitive	Pediatric Quality of Life survey		X	X	X
	Cognitive and development		X		X
	Behavioral assessment		X		X
	Magnetic resonance imaging*		X		X
	Neuropsychological assessment*		X		X
Growth and Nutrition	Height and length	X	X	X	X
	Weight	X	X	X	X
	Head and mid-arm circumference	X	X	X	X
	Tanner stage	X	X	X	X
	3-day diet record, food frequency		X	X	X
	Physical activity		X	X	X
Inflammation	Wide-range C-reactive protein		X		X
Bone Health	Intact PTH		X		X
	Bone biopsy****		X		Year 2 only

^†Included renal panel, complete blood count, and urine pregnancy test

^*goal to do in 30 patients at select centers

^**based on iohexol clearance

^***measured by high-performance liquid chromatography

^****goal to conduct 10.

Abbreviations: mGFR, measured glomerular filtration rate; UPCR, urine protein-creatinine ratio; eGFR, estimated glomuler filtration rate; ABPM, ambulatory blood pressure monitoring; IMT, intramedial thickness; PTH, parathyroid hormone.