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. Author manuscript; available in PMC: 2012 Nov 13.
Published in final edited form as: Mol Cell. 2012 Sep 20;48(3):343–352. doi: 10.1016/j.molcel.2012.08.017

Figure 5. PUMA and NOXA Are Critical for TAp63-Induced Apoptosis.

Figure 5

DNA damage leads to activation of TAp63, resulting in transcriptional induction of Puma and Noxa (which may be direct or indirect), with subsequent binding of PUMA and NOXA proteins to pro-survival BCL-2-family members (Bcl-2, Bcl-xL, Bcl-w, Mcl-1 or A1) and possibly also direct binding of PUMA to BAX/BAK. This causes activation of BAX and BAK, resulting in apoptotic cell death.