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Photomicrographs showing the effect of simvastatin on axonal injury in the ipsilateral hemisphere 14 days after TBI. Treatment with simvastatin significantly increases synaptic density compared with saline control group (A-D). Simvastatin increases the axonal density (E-H & M-P) and reduces the density of APP-positive axons (I-L) compared with the saline-treated group. Data represent mean ± SD. The scale bars = 50 m (for all panels). n = 8/group.
