Figure 1.

Mvt1 tumor growth and metastasis development are more rapid in MKR^+/+ mice compared to controls. A total 100,000 Mvt1 cells were injected into the left inguinal mammary fat pad of control and MKR^+/+ mice (8 to 10 per group). (A) Mammary tumor volume (mm³) measured by calipers. (B) Terminal weights of Mvt1-induced mammary tumors. (C) Numbers of pulmonary macrometastases in control and MKR^+/+ mice. (D) H & E staining of control and MKR^+/+ lungs, arrows indicate metastases. Error bars represent SEM *, P ≤ 0.05.