Table 5.

Associations with estrogen receptor-positive and estrogen receptor-negative breast cancer risk for BRCA1 and BRCA2 carriers.

					ER-positive			ER-negative
	Unaffected N	ER-positive N	ER-negative N	ER status unknown N	HR	95% CI	P-value	HR	95% CI	P-value	P-dif
CDK2NA/B - rs1011970
BRCA1	4,893	559	1,888	2,841	0.95	0.81 to 1.12	0.56	1.03	0.95 to 1.11	0.47	0.41
BRCA2	2,928	1,372	424	1,649	1.10	1.00 to 1.22	0.05	1.15	0.96 to 1.37	0.12	0.70
ZNF365 - rs10995190
BRCA1	4,895	559	1,887	2,843	0.88	0.74 to 1.04	0.14	1.01	0.94 to 1.10	0.75	0.16
BRCA2	2,927	1,370	406	1,648	0.89	0.80 to 1.00	0.043	0.87	0.71 to 1.07	0.19	0.84
ZMIZ1 - rs704010
BRCA1	4,842	548	1,846	2,811	1.12	1.00 to 1.26	0.046	1.00	0.94 to 1.06	0.91	0.08
BRCA2	2,887	1,347	401	1,636	1.01	0.93 to 1.09	0.91	1.00	0.87 to 1.14	0.95	0.91
10p15 - rs2380205
BRCA1	4,465	540	1,812	2,513	0.90	0.80 to 1.01	0.08	1.02	0.96 to 1.09	0.46	0.06
BRCA2	2,701	1,341	396	1,543	1.02	0.95 to 1.10	0.60	0.94	0.82 to 1.08	0.39	0.31
11q13 - rs614367
BRCA1	4,879	557	1,886	2,832	1.09	0.93 to 1.29	0.30	1.04	0.96 to 1.12	0.40	0.59
BRCA2	2,921	1,365	405	1,639	1.06	0.96 to 1.17	0.26	0.84	0.69 to 1.04	0.10	0.05
12q24 - rs1292011
BRCA1	3,429	308	1,043	2,031	0.87	0.74 to 1.02	0.09	1.05	0.98 to 1.13	0.12	0.046
BRCA2	2,065	813	239	1,170	0.95	0.86 to 1.04	0.28	0.98	0.82 to 1.16	0.78	0.79
PTHLH - rs10771399
BRCA1	4,889	557	1,887	2,842	0.94	0.78 to 1.13	0.52	0.81	0.74 to 0.90	3.8 × 10-5	0.20
BRCA2	2,926	1,366	406	1,648	0.97	0.86 to 1.10	0.68	0.78	0.62 to 1.00	0.049	0.12
9q31.2 - rs865686
BRCA1	4,892	559	1,888	2,836	0.92	0.81 to 1.03	0.15	1.01	0.95 to 1.08	0.68	0.16
BRCA2	2,924	1,370	405	1,645	0.91	0.84 to 0.99	0.028	1.07	0.92 to 1.25	0.40	0.08

ER, estrogen receptor; HR, hazard ratio