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. 2012 Oct 24;32(43):15027–15035. doi: 10.1523/JNEUROSCI.2545-12.2012

Figure 3.

Figure 3.

Dark exposure shifts the thresholds for the induction of LTP and LTD with rate-dependent paradigms (A–D) and depolarization-pairing paradigms (E, F). A–D, Effects of dark exposure on the induction of synaptic plasticity of layer II/III FPs with rate-dependent paradigms (see Materials and Methods). A, Dark exposure reduces LTD of the FP amplitude induced with a 1 Hz tetanus (900 pulses). B, Dark exposure enables the induction of LTP of the FP amplitude with a 40 Hz tetanus (120 pulses). C, Dark exposure does not affect the induction of LTP with theta burst stimulation (TBS; 120 pulses in patterned bursts of 100 Hz; see Materials and Methods). D, Summary of the effects of dark exposure on the induction of plasticity at different stimulation frequencies. Asterisks denote p < 0.05. E, F, Effects of dark exposure on the induction of synaptic plasticity with voltage-pairing paradigms. G, Dark exposure reduces LTD of the EPSPs induced by pairing 120 stimulation pulses with postsynaptic depolarization to −40 mV. H, Dark exposure enables LTP of the EPSPs induced by pairing synaptic stimulation with postsynaptic depolarization to −10 mV. Plotted data are average ± SEM. G, Dark exposure does not affect LTD induced with 1 Hz in the presence of adrenergic agonists (10 μm Iso and 5 μm Mtx, gray bar). H, Summary of the effects of dark exposure on the induction of LTD with 1 Hz stimulation.