Figure 4.

Dark exposure extends the integration time for the induction for STDP. A, B, tLTP and tLTD were induced simultaneously in two pathways in the presence of an agonist mixture (10 μm Iso and 5 μm Mtx, 10 min). A, In cells from NR mice, no changes were induced when the delay between presynaptic and postsynaptic stimulation was 100 ms (filled circles) or −100 ms (open circles). B, The same pairing delays induced tLTP (open circles, 100 ms delay) and tLTD (filled circles, −100 ms delay) in cells from DE mice. C, Summary of changes in the EPSPs (30 min after conditioning) elicited by pre-post pairing with different time delays. Individual experiments are represented as circles (NR, open circles; DE, filled circles). Some data points are laterally displaced for viewing purposes. The lines connect the average changes for each delay from cells of NR mice (gray) and DE mice (filled circle). Plotted data are average ± SEM.