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gBK-specific CTLs will kill HLA-0201+ gliomas that also express gBK. gBK1- and gBK2-specific T cells were generated and tested against either LN18, T98G, U87, or U251 glioma (HLA-A0201+/gBK+) or D54 cells (HLA-A1+/A3+, gBK+) and LNZ308 (HLA-A24+, gBK+) in a 6-h assay. (A and B) Results of one representative study done three times that shows the results of the gBK1-specific CTLs. (C and D) Results generated with the gBK2-specific CTLs. *p < 0.05 from the non-HLA-A2− control values.
