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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Autoimmunity. 2012 Jun 25;45(6):440–448. doi: 10.3109/08916934.2012.682668

Figure 2.

Figure 2

Following immunization, young JHT.mIg mice with AID deficiency also exhibited an increased in naïve T cells. JHT.mIg.MRL/lpr and its AID-deficient counterpart (3 mice/group) were immunized with NP at 3 months of age and euthanized 2 weeks later. The impact of AID deficiency on the fraction of naïve and memory T cells in CD4+ (A) and CD8+ T (B) cells was similar to that seen in older mice. CD4+ and CD8+ T cells were defined as being naïve (CD44low, CD62high), activated (CD44high, CD62Lhigh), or memory (CD44high, CD62Llow). The error bars represent standard errors. Student’s t-test was performed.