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Predictive phenotype of MRL/lpr derived mouse strains
| Strain | mature B cells | mIgM | sIgM | mIgG sIgG | SHM | CSR |
|---|---|---|---|---|---|---|
| MRL/lpr (WT) | yes | yes | yes | yes | yes | yes |
| JHT.MRL/lpr | no | no | no | no | no | no |
| JHT.mIg.MRL/lpr | yes | Limited repertoire | no | no | yes | no |
| JHT.mIg.AID−/−MRL/lpr | yes | Limited repertoire | no | no | no | no |
mIgM, membrane IgM; sIgM, secreted IgM; mIgG, membrane IgG; sIgG, secreted IgG; SHM, somatic hypermutation; CSR, class switching recombination.
