Table 1.
Primary tumor (T) | |||||
TX | Primary tumor cannot be assessed | ||||
T0 | No evidence of primary tumor | ||||
Tis | High-grade dysplasia | ||||
T1 | Tumor invades lamina propria, muscularis mucosae, or submucosa | ||||
T1a | Tumor invades lamina propria or muscularis mucosae | ||||
T1b | Tumor invades submucosa | ||||
T2 | Tumor invades muscularis propria | ||||
T3 | Tumor invades adventitia | ||||
T4 | Tumor invades adjacent structures | ||||
T4a | Resectable tumor invading pleura, pericardium, or diaphragm | ||||
T4b | Unresectable tumor invading other adjacent structures aorta, vertebral body, trachea, etc | ||||
Regional lymph nodes (N) | |||||
NX | Regional lymph nodes cannot be assessed | ||||
N0 | No regional lymph node metastasis | ||||
N1 | Metastasis in 1–2 regional lymph nodes | ||||
N2 | Metastasis in 3–6 regional lymph nodes | ||||
N3 | Metastasis in seven or more regional lymph nodes | ||||
Distant metastasis (M) | |||||
M0 | No distant metastasis | ||||
M1 | Distant metastasis | ||||
Histologic grade (G) | |||||
GX | Grade cannot be assessed-stage grouping as G1 | ||||
G1 | Well-differentiated | ||||
G2 | Moderately differentiated | ||||
G3 | Poorly differentiated | ||||
G4 | Undifferentiated-stage grouping as G3 squamous | ||||
Squamous cell carcinomaa | |||||
| |||||
Stage | T | N | M | Grade | Tumor locationb |
| |||||
Anatomic stage/prognostic groups | |||||
Stage 0 | Tis | N0 | M0 | 1, X | Any |
Stage 1A | T1 | N0 | M0 | 1, X | Any |
Stage 1B | T1 | N0 | M0 | 2–3 | Any |
T2–3 | N0 | M0 | 1, X | Lower, X | |
Stage IIA | T2–3 | N0 | M0 | 1, X | Upper, Middle |
T2–3 | N0 | M0 | 2, 3 | Lower, X | |
Stage IIB | T2–3 | N0 | M0 | 2, 3 | Upper, Middle |
T1–2 | N1 | M0 | Any | Any | |
Stage IIIA | T1–2 | N2 | M0 | Any | Any |
T3 | N1 | M0 | Any | Any | |
T4a | N0 | M0 | Any | Any | |
Stage IIIB | T3 | N2 | M0 | Any | Any |
Stage IIIC | T4a | N1–2 | M0 | Any | Any |
T4b | Any | M0 | Any | Any | |
Any | N3 | M0 | Any | Any | |
Stage IV | Any | Any | M1 | Any | Any |
Adenocarcinoma | |||||
| |||||
Stage | T | N | M | Grade | |
| |||||
Stage 0 | Tis | N0 | M0 | 1, X | |
Stage 1A | T1 | N0 | M0 | 1–2, X | |
Stage 1B | T1 | N0 | M0 | 3 | |
T2 | N0 | M0 | 1–2, X | ||
Stage IIA | T2 | N0 | M0 | 3, X | |
Stage IIB | T3 | N0 | M0 | Any | |
T1–2 | N1 | M0 | Any | ||
Stage IIIA | T1–2 | N2 | M0 | Any | |
T3 | N1 | M0 | Any | ||
T4a | N0 | M0 | Any | ||
Stage IIIB | T3 | N2 | M0 | Any | |
Stage IIIC | T4a | N1–2 | M0 | Any | |
T4b | Any | M0 | Any | ||
Any | N3 | M0 | Any | ||
Stage IV | Any | Any | M1 | Any |
Notes:
Or mixed histology including a squamous component or NOS;
location of the primary tumor is defined by the position of the upper (proximal) edge of the tumor in the esophagus.