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Left. Step-by-step synthesis of CLIO-NRP-V7 probe; Right. Schematic representation of CLIO-NRP-V7 probe. Biotinylated NRP-V7/H-2Kd complex was coupled to CLIO particles modified with avidin. CLIO-NRP-V7 probe is recognized by the TCR on NRP-V7-reactive CD8+ T-cells. Note that there are four binding sites for biotin on avidin and, hence, for biotinylated peptide/MHC complex. Reproduced with permission from American Diabetes Association (42)
