Fig. 4.
Transverse and coronal PET images of s.c. HuH-7 tumor-bearing mice at 3 h after i.v. injection of 64Cu-cyclam-RAFT-c(-RGDfK-)4 (11.1 MBq) on the day after daily i.p. injections of (a) vehicle alone (50 μl of DMSO) or (b) TSU-68 (75 mg kg−1 d−1 in 50 μl of DMSO) for 14 days (n = 4 mice for each group). The arrows indicate the tumor location. Representative autoradiographic examination (c, e) and CD31 immunofluorescence staining (d, f) with the same whole-tumor sections from (c, d) vehicle- and (e, f) TSU-68-treated tumors excised after PET imaging. g MVD, ha′ SUVmean, and hb′ SUVmax were compared between TSU-68- and vehicle-treated tumors. All data presented in a–h are from the same set of experimental groups