Table 1.
Biodistribution of 64Cu-cyclam-RAFT-c(-RGDfK-)4 in HuH-7 tumor-bearing mice treated with TSU-68 or vehicle after 14 days of therapy
Organ | Vehicle (n = 5) | TSU-68 (n = 5) |
---|---|---|
Blood | 0.07 ± 0.01 | 0.05 ± 0.01a |
Heart | 0.59 ± 0.08 | 0.37 ± 0.06a |
Lung | 1.58 ± 0.24 | 1.08 ± 0.21a |
Liver | 5.37 ± 0.36 | 3.75 ± 0.46a |
Pancreas | 0.61 ± 0.13 | 0.55 ± 0.15 |
Spleen | 2.86 ± 0.49 | 1.65 ± 0.21a |
Stomach | 1.94 ± 0.34 | 1.40 ± 0.19a |
Intestine | 1.58 ± 0.14 | 0.96 ± 0.15a |
Kidney | 25.4 ± 3.48 | 16.5 ± 3.36a |
Skin | 2.21 ± 0.22 | 1.51 ± 0.28a |
Muscle | 0.31 ± 0.07 | 0.21 ± 0.03a |
Bone | 0.81 ± 0.23 | 0.47 ± 0.06a |
Tumor | 2.44 ± 0.93 | 1.57 ± 0.53a |
Tissue radioactivity was assessed 3 h after injection of 0.74 MBq of the tracer and is expressed as % ID/g (mean ± SD)
a P < 0.05 versus the vehicle-treated group