Table 2.
Biodistribution of 64Cu-cyclam-RAFT-c(-RGDfK-)4 in HuH-7 tumor-bearing mice treated with TSU-68 or vehicle after 1 day of therapy
| Organ | Vehicle (n = 9) | TSU-68 (n = 9) |
|---|---|---|
| Blood | 0.11 ± 0.03 | 0.09 ± 0.02ns |
| Liver | 4.97 ± 0.80 | 5.19 ± 0.73ns |
| Kidney | 21.6 ± 3.84 | 24.1 ± 3.54ns |
| Muscle | 0.40 ± 0.06 | 0.53 ± 0.07ns |
| Tumor | 2.89 ± 0.84 | 2.17 ± 0.84a |
| Tumor MVD | 4.65 ± 1.15 | 4.09 ± 1.38b |
Tissue radioactivity was assessed 3 h after injection of 0.74 MBq of the tracer and is expressed as % ID/g (mean ± SD). The corresponding tumor MVD was presented as a percentage of the CD31-positive area
ns P > 0.05; a P = 0.085; b P = 0.36 versus the vehicle-treated group