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. 2012 Nov 15;23(22):4362–4372. doi: 10.1091/mbc.E12-04-0293

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© 2012 Donovan and Corbo. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 1: — Giant horizontal cells in Rb1-deficient retina. H&E-stained sections show marked thinning of all three nuclear layers in RbCKO retina at P26 (B) relative to controls (A). (B′, B′′) Boxed areas in B show grossly enlarged cells at the sclerad edge of the INL. Calbindin immunohistochemistry (red) confirms the identity of these enlarged cells in the mutant retina (D) compared with the control (Six3-Cre⁺;Rb1^Iox/+; C). Sections were counterstained with DAPI (blue, white) to visualize nuclei in control (C, E) and RbCKO (D, F) retinas. GCL, ganglion cell layer; INL, inner nuclear layer; ONL, outer nuclear layer. Scale bars, 25 μm.