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. 2012 Nov 15;23(22):4373–4382. doi: 10.1091/mbc.E12-04-0281

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© 2012 Cui et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 3: — Ndi1 translocates from mitochondria to cytoplasm during apoptosis. Ndi1-RFP is overexpressed, whereas Ndi1-TAP is under the endogenous regulation. (A) Ndi1-RFP maintains the proapoptotic function of Ndi1. (B) Ndi1-RFP is localized in the mitochondria under normal growth conditions but moves out during apoptosis. Om45-GFP is used to indicate mitochondria. Mn is used for apoptosis induction. (C, D) Ndi1-TAP colocalizes with mitochondrial inner membrane protein CoxIV, as detected by immunofluorescence and Western blot. (E) NDI1-TAP exhibited normal NADH dehydrogenase function like wild-type NDI1. It can use glycerol well. (F) Ndi1-TAP also shows similar apoptotic activity to the wild-type Ndi1. Bar, 1 μm.