Table 3.
KEGG pathway analysis for those genes whose mRNA expression was significantly associated with miRNA expression (p < 0.05)
| miRNA |
Correlated genes (n = 17208) |
SIGNIFICANTLY ENHANCED KEGG PATHWAYS (4 gene threshold) |
||
|---|---|---|---|---|
| p < 0.05 | q < 0.2 | KEGG Pathway name | (observe, expected, p-value) | |
|
miR-15b |
541 |
1 |
Focal adhesion |
(o = 10; e = 1.8; p = 2.8e-5) |
| Regulation of actin cytoskeleton |
(o = 10; e = 1.9; p = 4.2e-5) |
|||
| Long-term potentiation |
(o = 5; e = 0.6; p = 6.3e-4) |
|||
| Pancreatic cancer |
(o = 4; e = 0.7; p = 7.1e-3) |
|||
| Long-term depression |
(o = 4; e = 0.7; p = 7.7e-3) |
|||
| Axon guidance |
(o = 4; e = 1.3; p = 4.0e-2) |
|||
|
miR-212 |
858 |
0 |
MAPK signaling pathway |
(o = 12; e = 3.8; p = 7.1e-4) |
| Regulation og actin cytoskeleton |
(o = 10; e = 2.8; p = 7.4e-4) |
|||
| Calcium signaling pathway |
(o = 8; e = 2.4; p = 4.5e-3) |
|||
| Tight junction |
(o = 8; e = 1.6; p = 3.2e-4) |
|||
|
miR-34c |
532 |
0 |
MAPK signaling pathway |
(o = 12; e = 2.7; p = 3.3e-5) |
| Jak-STAT signaling pathway |
(o = 7; e = 1.5; p = 9.9e-4) |
|||
| Focal adhesion |
(o = 7; e = 1.9; p = 3.6e-3) |
|||
| Long-term depresion |
(o = 4; e = 0.7; p = 8.4e-3) |
|||
|
miR-31 |
586 |
0 |
Regulation of actin cytoskeleton |
(o = 11; e = 2.1; p = 1.5e-5) |
| MAPK signaling pathway |
(o = 10; e = 2.9; p = 8.5e-4) |
|||
| Axon guidance |
(o = 9; e = 1.3; p = 1.5e-5) |
|||
| GnRH signaling pathway |
(o = 7; e = 1.0; p = 1.0e-4) |
|||
| Wnt signaling pathway |
(o = 6; e = 1.5; p = 5.5e-3) |
|||
| miR-301a | 927 | 0 | Focal adhesion |
(o = 13; e = 3.1; p = 2.5e-5) |
| Regulation of actin cytoskeleton |
(o = 11; e = 3.2; p = 6.0e-4) |
|||
| MAPK signaling pathway |
(o = 10; e = 4.4; p = 1.6e-2) |
|||
| Colorectal cancer |
(o = 7; e = 1.4; p = 6.5e-4) |
|||
| Long-term potentiation | (o = 4; e = 1.1; p = 2.5e-2) | |||