Figure 2. Complement activation initiated by auto-antibodies in type 1 diabetic serum induce a specific profile of gene expression. Islets exposed to complement in diabetic serum or control sera (allogenic or autologous) were compared using Illumina micro-array analysis. The resulting data was analyzed using the GeneSpring Software. Supervised clustering revealed 679 differentially expressed genes in diabetic serum when compared with autologous serum. Data from one representative experiment out of five independent experiments is shown.