Table 6. Association of combined blood groups and CR1 polymorphisms (intron 27 and exon 22) with P. falciparum malaria.
| Combined | Clinical categories, % of subject | CM vs UM | MOD vs UM | NCSM vs UM | SM vs UM | ||||||||
| Blood group/intron 22/exon 27 | CM(n = 75) | MOD(n = 93) | NCSM(n = 101) | SM(n = 269) | UM (n = 119) | OR(95% CI) | P Value | OR (95% CI) | P Value | OR (95% CI) | P value | OR (95% CI) | P value |
| O+/AA/AA | 3 (4) | 3 (3) | 3 (3) | 9 (3) | 6 (5) | 1 | Ref | 1 | ref | 1 | Ref | ref | |
| O+/AA/AT+TT | 1 (1) | 1 (1) | 2 (2) | 4 (1.5) | 2 (2) | 1.00 (0.06 to16.00) | 1.00 | 1.00 (0.06 to16.00) | 1.00 | 2.00 (0.18 to 22.07) | 1.00 | 1.33 (0.18 to 9.73) | 1 |
| O+/AG+GG/AA | 3 (4) | 6 (6.5) | 2 (2) | 11 (4) | 3 (3) | 2.00 (0.24 to 16.62) | 0.62 | 4.00 (0.56 to 28.41) | 0.34 | 1.33 (0.13 to 12.83) | 1.00 | 2.44 (0.47 to 12.63) | 0.42 |
| O+/AG+GG/AT+TT | 9 (12) | 14 (15) | 25 (25) | 48 (18.5) | 42 (34) | 0.42 (0.08 to 2.04) | 0.36 | 0.66 (0.14 to 3.02) | 0.68 | 1.19 (0.27 to 5.18) | 1.00 | 0.76 (0.25 to 2.31) | 0.78 |
| A+/AA/AA | 1 (1) | 4 (4) | 1 (1) | 6 (2) | 3 (3) | 0.66 (0.04 to 9.47) | 1.00 | 2.66 (0.34 to 20.52) | 0.61 | 0.66 (0.04 to 9.47) | 1.00 | 1.33 (0.23 to 7.51) | 1. |
| A+/AA/AT+TT | 0 | 2 (2) | 0 | 2 (1) | 0 | – | – | – | – | – | – | – | – |
| A+/AG+GG/AA | 1 (1) | 6 (6.5) | 2 (2) | 9 (3) | 4 (3) | 0.50 (0.03 to 6.68) | 1.00 | 3.00 (0.45 to 19.60) | 0.36 | 1.00 (0.11 to 8.95) | 1.00 | 1.50 (0.31 to 7.18) | 0.70 |
| A+/AG+GG/AT+TT | 7 (9) | 7 (8) | 15 (15) | 29 (11) | 18 (14.5) | 0.77 (0.15 to 4.00) | 1.00 | 0.77 (0.15 to 4.00) | 1.00 | 1.66 (0.35 to 7.82) | 0.70 | 1.07 (0.32 to 3.52) | 1.00 |
| B+/AA/AA | 17 (24) | 17 (18) | 8 (8) | 42 (15.5) | 2 (2) | 17.00 (2.26 to 127.8) | 0.004 | 17.00 (2.26 to 127.8) | 0.004 | 8.00 (1.00 to 64.00) | 0.06 | 14.00 (2.42 to 80.99) | 0.002 |
| B+/AA/AT+TT | 1 (1) | 1 (1) | 1 (1) | 3 (1) | 1 (1) | 2.00 (0.09 to 44.38) | 1.00 | 2.00 (0.09 to 44.38) | 1.00 | 2.00 (0.09 to 44.38) | 1.00 | 2.00 (0.16 to 24.08) | 1.00 |
| B+/AG+GG/AA | 9 (12) | 7 (8) | 6 (6) | 22 (8) | 2 (2) | 9.00 (1.14 to 71.07) | 0.06 | 7.00 (0.86 to 56.92) | 0.15 | 6.00 (0.72 to 49.86) | 0.15 | 7.33 (1.23 to 43.43) | 0.037 |
| B+/AG+GG/AT+TT | 15 (20) | 20 (22) | 29 (28) | 64 (24) | 18 (14.5) | 1.66 (0.35 to 7.82) | 0.70 | 2.22 (0.48 to 10.22) | 0.46 | 3.22 (0.71 to 14.53) | 0.15 | 2.37 (0.74 to 7.54) | 0.19 |
| AB+/AA/AA | 2 (3) | 0 | 1 (1) | 3 (1) | 0 | – | – | – | – | – | – | – | – |
| AB+/AA/AT+TT | 0 | 0 | 0 | 0 | 1 (1) | – | – | – | – | – | – | – | – |
| AB+/AG+GG/AA | 3 (4) | 0 | 1 (1) | 4 (1.5) | 3 (3) | 2.00 (0.24 to 16.62) | 0.62 | – | – | 0.66 (0.04 to 9.47) | 1.00 | 0.88 (0.14 to 5.48) | 1.00 |
| AB+/AG+GG/AT+TT | 3 (4) | 5 (5) | 5 (5) | 13 (5) | 14 (12) | 0.42 (0.06 to 2.76) | 0.62 | 0.71 (0.12 to 3.99) | 1.00 | 0.71 (0.12 to 3.99) | 1.00 | 0.61(0.17 to 2.22) | 0.53 |
NOTE: Data are no. (%) of participants unless otherwise specified. UM: uncomplicated malaria; CM: cerebral malaria; MOD: multi-organ dysfunction; NCSM: non-cerebral severe malaria; OR: odds ratio; CI: confidence interval.