Figure 3. Effects of Snail signaling in prostate cancer and promising therapeutic targets. Snail gene is involved in canonical pathways that induce EMT associated with a transition from an epithelial to mesenchymal morphology, decreased cell adhesion and increased invasion and migration. Snail is also involved in non-canonical pathways such as bone turnover in which cancer cells produce RANKL that stimulates osteoclast maturation and increased bone resorption and NED in which cancer cells acquire long neurite processes and produce factors that promote paracrine cell proliferation. Several promising therapies that can antagonize Snail are �shown.