Table 3. Biodistribution of liposomes following CED to F98 glioma bearing rats.
| Mean cisplatin concentrations (µg/g) ± SDc | |||||
| Groupa | Tumor | Brain aroundb tumor (BAT) | Brain (R) | Brain (L) | Bloodd |
| 0 h | 4.4±0.9 | 2.2±1.4 | 0.3±0.4 | 0.6±0.7 | <0.01 |
| 24 h | 2.8±0.2c | 1.3±1.0 | 0.1±0.2 | 0.8±0.3 | <0.01 |
a
F98 glioma cells were implanted into the right caudate nucleus of 8 Fischer rats. Twelve to 14 d later, they received CED of cisplatin containing CHEMS liposomes (9.6 µg in 10 µl over 30 min) and were euthanized either immediately following (t = 0 h.) CED or 24 h later. The tumors, BAT and normal brain and blood samples were collected and Pt concentrations were determined by ICP-OES.
b
Brain around tumor arbitrarily included an area of 1 mm beyond the dissected margins of the tumor.
c
Means and standard deviations (SD) were calculated on values obtained from 4 rats for each time point.
d
The P-value<0.05 compared to that determined at t = 0. Other than this, there were no significant differences in the 0 and 24 h Pt values.