Table 1. miRNAs significantly deregulated between 13q- CLL subgroups (patients with 80% or more of cells with 13q deletion and patients with less than 80% 13q cells).
miRNA | Map | q-value | R fold |
Down-regulated | |||
hsa-mir-1-1* | 20q13.33 | 0.0125 | 0.7027 |
hsa-mir-7-1 | 9q21.32 | 0.0397 | 0.5453 |
hsa-mir-15a | 13q14.3 | 0.0329 | 0.4917 |
hsa-mir-29a | 7q32.3 | 0.0354 | 0.5101 |
hsa-mir-34a* | 1p36.23 | 0.0366 | 0.6874 |
hsa-mir-106b* | 7q22.1 | 0.0280 | 0.5190 |
hsa-mir-181b | 1q31.3 | 0.0256 | 0.6775 |
hsa-mir-204 | 9q21.11 | 0.0294 | 0.5693 |
hsa-mir-206 | 6p12.2 | 0.0476 | 0.7077 |
hsa-mir-221* | Xp11.3 | 0.0133 | 0.4622 |
hsa-mir-223* | Xq12 | 0.0017 | 0.1016 |
Up-regulated | |||
hsa-mir-134 | 14q32.31 | 0.0095 | 1.8096 |
hsa-mir-105-2 | Xq28 | 0.0182 | 1.4040 |
hsa-mir-155* | 21q21.3 | 0.0046 | 3.7013 |
hsa-mir-205 | 1q32.2 | 0.0161 | 1.3830 |
Upregulation or downregulation refers to 13q-H relative to13q-L CLL patients.
miRNA: microRNA.
deregulation shared with 17p/11q CLL patients.