Table 2. Quantitative transmission disequilibrium analysis (Abecasis’s orthogonal test) in 262 family trios with age of T1DM onset as a quantitative variable.

SNP	Minor allele	p-value*	Empirical p-value**	Optimal Genetic Model
rs2358817	T	0.782	0.778	Additive
rs1049550	A	0.098	0.144	Additive
rs6679356	C	0.005	0.003	Dominant
rs9865818	G	0.544	0.541	Additive

^*Nominal p values are shown uncorrected for multiple testing. The Bonferroni-corrected significance threshold was p = 0.0125.

^**Empirical p-values were obtained using 10000 Monte Carlo permutations. Empirical significance threshold of 0.05 corresponded to a p-value of <0.0128.