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Free energy of cyclization and nucleosome formation. Difference free energies for wrapping of different 94 bp DNAs around the core histone H32H42 tetramer are plotted against the difference free energies of cyclization for these same DNAs.74 The line illustrates the least-squares fit to the data. The slope of the line is one, implying that the entirety of the difference in affinity for wrapping around histones can be explained by the difference in the ability to cyclize.
