Table 4. Characteristics by Cardiac Magnetic Resonance (CMR)-derived Median Left Ventricular Mass Index (LVMi).
Variable | CMR-LVMi (<55 mg/m2) (n=45) |
CMR-LVMi (>55 mg/m2) (n=46) |
p Value |
---|---|---|---|
Age of chemotherapy (yrs) | 42 (18) | 43 (17) | 0.69 |
Male | 24 (45%) | 29 (55%) | 0.39 |
Chest radiation | 19 (63%) | 11 (37%) | 0.07 |
Anthracycline dose (mg/m ) | 317 (76) | 235 (63) | <0.0001 |
Major adverse cardiac events | 40 (77%) | 12 (23%) | <0.0001 |
Chemo to heart failure (months, mean, mths) | 91 (81) | 105 (90) | 0.43 |
Heart failure stage C | 39 (52%) | 35 (48%) | 0.28 |
Diabetes Mellitus | 6 (55%) | 5 (45%) | 0.75 |
Hypertension | 18 (51%) | 17 (49%) | 0.83 |
Atrial fibrillation | 10 (50%) | 10 (50%) | 1.00 |
Systolic blood Pressure (mmHg) | 116 (15) | 115 (17) | 0.51 |
Diastolic blood Pressure (mmHg) | 73 (13) | 70 (11) | 0.21 |
Heart rate (beats/min) | 71 (13) | 74 (13) | 0.37 |
Medication | |||
ACE/ARB | 38 (51%) | 37 (49%) | 0.78 |
Beta-blocker | 38 (51%) | 37 (49%) | 0.76 |
Spironolactone | 13 (62%) | 8 (38%) | 0.12 |
QRS duration (ms) | 96 (14) | 96 (18) | 0.99 |
Glomerular filtration rate (ml/min/1.73m ) | 72 (23) | 84 (23) | 0.02 |
Echocardiography: | |||
Estimated pulmonary artery systolic pressure (mmHg) | 33 (10) | 33 (10) | 0.95 |
Left ventricular mass index by echo (gm/m2) | 80 (19) | 76 (16) | 0.33 |
Cardiac Magnetic Resonance | |||
Indexed left ventricular end diastolic volume (ml/m2) | 97 (21) | 88 (21) | 0.05 |
Indexed left ventricular end systolic volume (ml/m ) | 63 (18) | 55 (14) | 0.04 |
Left ventricular ejection fraction (%) | 36 (8) | 36 (7) | 0.62 |
Indexed right ventricular end diastolic volume (ml/m2) | 80 (20) | 77 16) | 0.38 |
Indexed right ventricular end systolic volume (ml/m ) | 44 (15) | 42 (15) | 0.56 |
Right ventricular ejection fraction (%) | 45 (9) | 46 (10) | 0.68 |
Relative T2 signal intensity | 1.4 (0.2) | 1.5 (0.2) | 0.36 |
Late gadolinium enhancement | 3 (7%) | 2 (4%) | 0.56 |
Late gadolinium enhancement volume | 8.9 (4.6) | 4.4 (1.1) | 0.22 |
All data are mean (SD) unless otherwise indicated