Table 2.
Summary of Gene Expression Findings
| Gene | Brain Region | Basal bHR/bLR differences | Impact of neonatal FGF2 |
|---|---|---|---|
|
| |||
| TH | VTA | decreased in bLR vs bHR | decreased |
| DAT | VTA | - | - |
| D2 | VTA | - | - |
| FGF2 | VTA | decreased in bLR vs bHR | - |
| FGFR1 | VTA | - | - |
|
| |||
| TH | SN | - | - |
| DAT | SN | - | - |
| D2 | SN | - | - |
| FGF2 | SN | decreased in bLR vs bHR | - |
| FGFR1 | SN | - | - |
|
| |||
| D1 | AcbC | decreased in bLR vs bHR | increased in bLR ONLY |
| D2 | AcbC | increased in bLR vs bHR | - |
| FGF2 | AcbC | decreased in bLR vs bHR | increased in bLR ONLY |
| FGFR1 | AcbC | - | - |
|
| |||
| D1 | AcbSh | decreased in bLR vs bHR | decreased in bHR ONLY |
| D2 | AcbSh | - | - |
| FGF2 | AcbSh | - | - |
| FGFR1 | AcbSh | - | - |
|
| |||
| D1 | Cpu | - | decreased in bHR ONLY |
| D2 | Cpu | increased in bLR vs bHR | - |
| FGF2 | Cpu | decreased in bLR vs bHR | - |
| FGFR1 | Cpu | - | - |
Abbreviations: tyrosine hydroxylase (TH); dopamine transporter (DAT); dopamine receptor 2 (D2); Fibroblast Growth Factor 2 (FGF2); Fibroblast Growth Factor Receptor 1 (FGFR1); ventral tegmental area (VTA); substantia nigra (SN); nucleus accumbens core (AcbC); nucleus accumbens shell (AcbSh); caudate putament (Cpu)