Table 1.
Matrix effects of oseltamivir (OS), oseltamivir carboxylate (OSC), deuterated oseltamivir (OS-d3), and deuterated oseltamivir carboxylate (OSC-d3) in human plasma
| Compounds | Concentration (ng/mL) |
Blank A (%), absolute ME |
Blank B (%), absolute ME |
Blank C (%), absolute ME |
Average (%), absolute ME |
CV (%), relative ME |
|---|---|---|---|---|---|---|
| 4.1 | 107 | 97 | 99 | 101 | 4.9 | |
| OS | 37.1 | 85 | 107 | 114 | 102 | 14.5 |
| 333 | 103 | 109 | 103 | 105 | 3.1 | |
| 4.1 | 83 | 90 | 91 | 88 | 5.3 | |
| OSC | 37.1 | 92 | 97 | 97 | 96 | 3.0 |
| 333 | 91 | 98 | 94 | 95 | 3.8 | |
| OS-d3 | 100 | 99 | 105 | 102 | 102 | 3.0 |
| OSC-d3 | 100 | 90 | 99 | 94 | 94 | 5.1 |
ME, matrix effect; Blank A (or B, C), blank plasma from three different human subjects.