Table 2.

Accuracy and precision (RSD) for assay of oseltamivir (OS) and oseltamivir oseltamivir carboxylate (OSC) in human plasma

Nominal concentration (ng/mL)	Within-run (n = 3)		Between-run (n = 3)
	Measured concentration (ng/mL) mean ± SD (RSD)	Accuracy	Measured concentration (ng/mL) mean ± SD (RSD)	Accuracy
OS
0.34 (LLOQ)	0.33 ! 0.04 (11.0%)	97%	0.36 ! 0.04 (9.9%)	106%
4.1	3.90 ! 0.09 (2.2%)	95%	3.93 ± 0.07 (1.8%)	96%
37.1	37.1 ! 1.0 (2.7%)	100%	37.1 ± 0.8 (2.2%)	100%
333	339 ! 9 (2.5%)	102%	336 ± 8 (2.5%)	101%
OSC
0.34 (LLOQ)	0.36 ! 0.03 (9.7%)	104%	0.37 ! 0.03 (7.7%)	110%
4.1	4.04 ! 0.15 (3.7%)	98%	4.11 ± 0.14 (3.4%)	100%
37.1	37.5 ! 1.0 (2.6%)	101%	37.3 ± 0.8 (2.2%)	101%
333	339 ± 10 (3.0%)	102%	336 ± 8 (2.4%)	101%

The human plasma was treated with sodium fluoride before use.