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. 2012 Sep 11;45(5):301–308. doi: 10.1267/ahc.12020

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© 2012 The Japan Society of Histochemistry and Cytochemistry

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 5 — Chromophobe renal cell carcinoma, eosinophilic variant. Insets show higher-magnification views of the regions indicated by arrows. The tumor is mainly composed of tumor cells that are smaller and markedly eosinophilic, and often showed a perinuclear halo (A). The tumor cells show diffuse fine granular cytoplasmic staining reaction with anti-KL-6 antibody (B). In addition, immunostaining is seen at the luminal surface of tubules (B). Pretreatment with neuraminidase decreases immunoreactivity with anti-KL-6 antibody (C). The tumor cells show diffuse fine granular cytoplasmic staining reaction with anti-sialyl MUC1 antibody (D). In addition, immunostaining is seen at the luminal surface of tubules (D). Pretreatment with neuraminidase abolishes immunoreactivity with anti-sialyl MUC1 antibody (E).