Table 1.
Demographic details of cases used in this study
| |
Control group |
Bipolar disorder group |
Schizophrenia group |
|---|---|---|---|
| (n = 35) | (n = 34) | (n = 35) | |
| Diagnostic subtype |
- |
BP1 = 27, BP2 = 4, BPNOS = 2, schizoaffective = 1 |
SCZ(disorganised) = 1, SCZ(paranoid) = 8, SCZ(undifferentiated) = 26 |
| Age (years) |
44.2 (31–60) |
45.4 (19–64) |
42.6 (19–59) |
| Gender |
9 F, 26 M |
18 F, 16 M |
9 F, 26 M |
| Hemisphere |
16 L, 19R |
19 L, 15R |
17 L, 18R |
| pH |
6.61 +/− 0.27 |
6.43 +/− 0.30 |
6.48 +/− 0.24 |
| PMI (hours) |
29.4 +/− 12.9 |
37.9 +/− 18.6 |
31.4 +/− 15.5 |
| RIN |
7.23 +/− 0.87 |
7.34 +/− 0.88 |
7.36 +/− 0.61 |
| Manner of death |
natural = 35 |
natural = 19, suicide = 15 |
natural = 28, suicide = 7 |
| Age of onset (years) |
- |
25.3 +/− 9.2 |
21.3 +/− 6.1 |
| Duration of illness (years) |
- |
20.2 +/− 9.6 |
21.3 +/− 10.2 |
| Lifetime antipsychotics (fluphenazine equivalents, mg) |
- |
10212 +/−22871 |
85004 +/− 100335 |
| Antidepressant use |
yes = 0, no = 35 |
yes = 19, no = 15 |
yes = 9, no = 26 |
| Type of antidepressant* |
- |
SSRI = 9 (fluoxetine = 5) SNRI = 4, SARI = 5, TCA = 6, other = 1 |
SSRI = 4 (fluoxetine = 2), SNRI = 0, SARI = 2, TCA = 2, other = 2 |
| Smoking around time of death | yes = 9, no = 9, unknown = 17 | yes = 15, no = 6, unknown = 13 | yes = 23, no = 4, unknown = 8 |
Demographic details of controls, bipolar disorder cases and schizophrenia cases used in this study. *Note- some individuals took multiple antidepressant medications. Abbreviations: BP1 = bipolar disorder type I, BP2 = bipolar disorder type II, BPNOS = bipolar disorder not otherwise specified, SCZ = schizophrenia, M = male, F = female, L = left, R = right, PMI = post-mortem interval, RIN = RNA integrity number, SSRI = selective serotonin reuptake inhibitor, SNRI = serotonin–norepinephrine reuptake inhibitor, SARI = serotonin antagonist and reuptake inhibitor, TCA = tricyclic antidepressant. Data quoted are mean (range) +/− standard deviation.