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Inhibition of Eis homologues from A. variabilis, M. smegmatis, and M. tuberculosis by compounds 1–5 for NEO acetylation
| Compound | IC50/μM
|
||
|---|---|---|---|
| Eis_Ava | Eis_Msm | Eis_Mtba | |
| 1 | 20 ± 7 | 1.85 ± 0.39 | 0.188 ± 0.030 |
| 2 | >200 | 0.925 ± 0.201 | 1.09 ± 0.14 |
| 3 | >200 | 1.69 ± 0.32 | 1.24 ± 0.16 |
| 4 | >200 | 0.455 ± 0.092 | 2.01 ± 0.12 |
| 5 | >200 | >200 | 2.29 ± 0.52 |
These data were previously reported.11
