Table 1.
Groups | AST (U/L) | ALT (U/L) | BUN (mmol/L) | Creatinine (μmol/L) | Hbg (g/L) | PLT (×109/L) | WBC (×109/L) | Lymphocyte (×109/L) | Neutrophil (×109/L) |
Control | 92.79 ± 8.74 | 49.73 ± 4.83 | 23.74 ± 5.84 | 0.23 ± 0.09 | 117.32 ± 9.87 | 69.43 ± 8.94 | 6.32 ± 1.24 | 3.86 ± 1.34 | 2.18 ± 0.73 |
GC | 92.34 ± 7.65d | 49.89 ± 5.13d | 23.25 ± 6.54 | 0.24 ± 0.08 | 118.823 ± 10.85 | 71.43 ± 6.54d | 6.53 ± 1.32d | 3.95 ± 1.35d | 2.17 ± 0.68 |
5-FU | 113.25 ± 7.65b | 81.48 ± 6.81b | 23.64 ± 5.45 | 0.25 ± 0.07 | 109.41 ± 10.73 | 55.63 ± 7.43a | 3.83 ± 1.18b | 1.57 ± 1.20a | 2.75 ± 0.87 |
GC/5-FU | 93.42 ± 8.32d | 48.97 ± 4.93d | 22.94 ± 5.26 | 0.24 ± 0.05 | 116.38 ± 8.53 | 68.64 ± 7.38c | 6.21 ± 1.04d | 3.81 ± 1.17c | 2.17 ± 0.71 |
F value | 8.227 | 33.222 | 0.020 | 0.058 | 0.868 | 4.349 | 5.498 | 4.249 | 0.712 |
P value | 0.002 | 0.000 | 1.012 | 0.941 | 0.482 | 0.018 | 0.008 | 0.024 | 0.526 |
Data were expressed as mean ± SD. n = 5 in each group.
P < 0.05,
P < 0.01 vs control group;
P < 0.05,
P < 0.01 vs 5-fluorouracil group. AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; BUN: Blood urea nitrogen; Hbg: Hemoglobin; PLT: Platelet; WBC: White blood cell; GC: Galactosylated chitosan; 5-FU: 5-fluorouracil.