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. Author manuscript; available in PMC: 2012 Nov 14.
Published in final edited form as: Alcohol Clin Exp Res. 2008 Dec 13;33(3):408–418. doi: 10.1111/j.1530-0277.2008.00860.x

Fig. 1.

Fig. 1

Clonidine synergistically enhances ethanol-evoked behavioral impairment. Rotorod time courses (A), corresponding area under the curve (AUC, B), and LORR durations (C) are shown for groups pretreated i.c. with aCSF prior to 2 i.v. injections of: (i) saline + saline (Sal or Saline), (ii) 60 μg/kg clonidine + saline (Clon or Clonidine), (iii) saline + 1 g/kg ethanol (EtOH or Ethanol), or (iv) 60 μg/kg clonidine + 1 g/kg ethanol (Clon + EtOH). The number of animals per group is shown in parentheses above the bar graphs. (Note: A few additional animals were tested for LORR only in the Clon + EtOH group.) p < 0.05, *differs from Sal, Clon, and EtOH (rotorod trends also differed from Clon + EtOH). Clon + EtOH AUC was significantly greater than the sum of the AUC for Clon and EtOH (synergistic interaction).